CLINICAL-STUDY OF A PATIENT WITH LUPUS VULGARIS BEFORE AND AFTER INJECTION OF DIALYZABLE TRANSFER-FACTOR

[摘要] The clinical improvement and acquisition of tuberculin skin-test sensitivity by a tuberculin-negative, drug-resistant patient with lupus vulgaris after a single injection of dialyzable transfer factor (TFd) from a tuberculin-positive healthy donor is described. The patient''s lymphocytes showed a slight response to tuberculin in the leukocyte migration inhibition test and in the lymphocyte transformation test before TFd injection. The acquisition of cellular immunity to tuberculin was demonstrated in vitro by enhanced tuberculin-induced blast transformation. A good correlation between skin test and in vitro tuberculin sensitivity and clinical improvement was seen during the 3 yr that the patient was observed.