ANTIMYCOTIC PROPERTIES OF THIABENDAZOLE

[摘要] Thiabendazole is a potent anthelmintic which was demonstrated to be highly active in vitro against a variety of saprophytic and pathogenic fungi. It is particularly active against strains of trichophyton and microsporum, and it also inhibits the growth of cultures producing mycotoxins. Serum does not affect its antifungal activity. Moderate amounts of the drug are absorbed following oral administration, and serum from dogs treated perorally or intravenously with thiabendazole inhibits the growth of pathogenic fungi in vitro. It is unusually well tolerated by a variety of animal species even when given daily over a 2-yr. period.