THE PHOTODYNAMIC ACTION OF NEUTRAL RED ON RABBIT BASOPHILS

[摘要] Rabbit basophils were stained with neutral red and then exposed to varying amounts of white light. The preparations were then examined microscopically and the percentage of abnormal cells determined. A direct photodynamic action of neutral red dye on rabbit basophils was demonstrated. This was partially blocked by the interposition of a neutral red filter between the light source and the stained cells. The recommendation is made that further studies on the basophil depletion test used for the detection of drug allergy be carried out with precautions to minimize exposure of the system to light.