SOME ENDOCRINE ASPECTS OF SKIN SENSITIZATION AND PRIMARY IRRITATION .4. OBSERVATIONS ON THE INFLUENCE OF THYROID DEFICIENCY AND ADMINISTRATION OF THYROID HORMONE UPON CUTANEOUS IRRITATION AND SENSITIZATION REACTIONS

[摘要] Thyroid hormone (thyroid extract U.S.P.) administered in large, intoxicating doses depresses the reactivity of the skin to 2,4-dinitrochlorobenzene applied to sensitized guinea pigs. Skin reaction to croton oil, as a primary irritant, is also depressed. Small doses of thyroxin, which in guinea pigs do not seem to give rise to systemic impairment apparently do not markedly interfere with cutaneous sensitivity to 2,4-dinitrochlorobenzene in sensitized animals. On the other hand, 400 [mu]g. thyroxin per kg. body weight intramuscularly 3 times a week, enhances cutaneous reactivity to 2,4-dinitrochlorobenzene, whether or not the animals are thyroidectomized. In most instances, thyroidectomy does not seem to alter skin responses to primary irritants. In sensitized guinea pigs, the skin responses to 1% 2,4-dinitrochlorobenzene dissolved in olive oil are not influenced by iontophoresis with thyroxin.