STUDIES ON THE ECZEMATOUS SENSITIZATION .4. SENSITIZATION TO METADINITROBENZENE AND ITS RELATION TO 2-4 DINITROCHLOROBENZENE

[摘要] A review of the theory regarding the chemical characteristics of compounds that are able to elicit a reaction in an animal eczematously sensitized to some other compound was given. This theory was explicitly discussed with respect to 2:4 dinitrochlorobenzene and metadinitrobenzene. It was pointed out that metadinitrobenzene is incapable of causing a reaction in the eczematously sensitive animal, presumably, because it cannot form appropriate conjugates in sufficient concentration within a requisite time. It was, however, shown that metadinitrobenzene can engender a sensitivity to a metadinitrophenyl protein conjugate, so that when the animal is subsequently tested with 2:4 dinitrochlorobenzene the animal will be found to be sensitive. Metadinitrobenzene was found to be incapable of inhibiting reactions to 2:4 dinitrochlorobenzene or to affect the duration of a sensitization to 2:4 dinitrochlorobenzene.