NEUTROPHIL LEUKOCYTE MIGRATION IN PSORIASIS-VULGARIS

[摘要] Neutrophil migration in patients with psoriasis vulgaris was assessed using in vitro and in vivo techniques. In vitro chemotaxis towards endotoxin-activated serum and casein was normal. Random filter migration increased in patients with extensive lesions. No significant difference was observed between effects of psoriatic and normal serum on control leukocyte in vitro migration. In vivo skin window chamber random migration and chemotaxis towards 50% autologus serum were normal in uninvolved skin, regardless of disease severity. Previous reports of abnormal leukocyte chemotaxis in psoriasis was not confirmed. Neutrophil migration into psoriatic plaques in vivo was the result of a local accumulation of chemotactic factors rather than of enhanced leukocyte chemotactic activity.