LASER DOPPLER MEASUREMENT OF CUTANEOUS BLOOD-FLOW

[摘要] An instrument for noninvasive measurement of cutaneous blood flow velocity is described. The system utilized the Doppler shift of laser light backscattered from moving red blood cells in the cutaneous microcirculation, the shift being obtained by an optical heterodyning technique. Comparison was made between this technique and the 133xenon clearance technique in measuring cutaneous flow in forearms of normal volunteers. Variations in flow were obtained in inducing different degrees of solar erythema with an ultraviolet sunlamp. A Y on X linear regression yielded a regression coefficient = 0.89 (P < 0.001, n [number] = 16) between the 2 methods. The laser Doppler method appeared to represent a practical technique for clinical evaluation of cutaneous blood flow in any skin surface.