INHIBITION OF ULTRAVIOLET-INDUCED CARCINOGENESIS BY ALL-TRANS RETINOIC ACID

[摘要] The effects of all-trans retinoic acid (RA) in 0.05%, 0.025% and 0.005% concentrations on UV induced carcinogenesis was investigated in the skin of Uscd strain hairless mice. A carcinogenic amount of UV energy was delivered over the 12 mo. period of the study. The 0.025% and 0.005% RA solutions did not alter the development of cutaneous cancers. The 0.05% RA concentration significantly inhibited the tumor formation.