HUMAN PHARMACOLOGY OF GRISEOFULVIN - THE EFFECT OF FAT INTAKE ON GASTROINTESTINAL ABSORPTION

[摘要] Serum griseofulvin levels in humans following a standardized oral test dose vary widely between individuals. The amount of serum griseofulvin following a test dose may be nearly doubled by administration with a high fat meal. The elevated levels are due to increased absorption of griseofulvin from the gastrointestinal tract rather than to slowed serum clearance. Evidence is presented that inadequate absorption of griseofulvin is one of the mechanisms of clinical failure with ordinary therapeutic doses.