EFFECT OF CHLORPROMAZINE ON OCULOCUTANEOUS PIGMENTATION IN GUINEA PIG

[摘要] Large doses of chlorpromazine were administered to albino, red and black guinea pigs in an attempt to reproduce the abnormal oculocutaneous pigmentation reported in the human subject. After giving the drug for a period of 12 months and exposing the shaved animals continuously to ultraviolet light, no dermal deposits of pigment were demonstrated. Slit lamp examination of the guinea pig eyes following the drug treatment revealed lens opacities in all the animals. These were composed of small white dots located in the anterior subcapsular area and also in the posterior cortex of the lens. They were identical with those reported in the human subject.