Notch and Melanocytes: Diverse Outcomes from a Single Signal

[摘要] Notch signaling is an evolutionally conserved pathway that serves as a critical regulator of cell fate. From a series of studies, including a report in this issue, researchers have begun to elucidate the critical functions of notch signaling in the regulation of melanocyte lineage development. With evidence of a recently identified role for notch signaling in melanomagenesis, characterization of downstream molecular events may offer potential avenues for the development of novel therapeutic strategies.

[发布日期] 2008-11-01