STUDIES WITH NEW FUNGISTATIC AGENTS .1. FOR THE TREATMENT OF SUPERFICIAL MYCOSES

[摘要] The following new substances to be used in 2.5% conc. or possibly less are most promising for clinical trial in the treatment of superficial mycoses: (1) Na2 ethylene-bis(dithiocarbamate), which is fungicidal at 1:1000 for 5 mins., is also bacteriostatic, especially against Gram-positive organisms and inhibits the growth of Escherichia coli at 1:10,000, Eberthella typhosa at 1:5000, and Staphylococcus aureus at 1:100,000; (2) Ca dimethyldithiocarbamate, which is not inactivated by blood, has a bacteriostatic effect somewhat less than that of the first mentioned substance; (3) ferric dimethyldithiocarbamate, and (4) phenanthra-quinone-9,10.