ANATOMY OF ECCRINE SWEAT GLANDS IN D1 G1 AND 18 AND 18 TRISOMY SYNDROMES

[摘要] The duct length, secretory coil size, and the ratio of the 2, were determined by measurement of microdissected eccrine sweat glands from series of patients clinically diagnosed as having the D1, 18 and G1 trisomy syndromes (trisomy 13-15, trisomy 16-18, and the Down syndrome). The findings were compared to those of a series of patients with Arnold-Chiari malformation, a developmental disorder of the central nervous system, and to a control population. With the reservation that only 12 of 49 patients clinically diagnosed as having one of the 3 chromosomal disorders were confirmed cytogenetically, patients with G1 trisomy were found to have eccrine sweat glands with long excretory ducts relative to the size of the secretory coils, and patients with 18 trisomy the reverse relation. The patients diagnosed as having D1 trisomy, and those with the Arnold-Chiari malformation had anatomically normal eccrine sweat glands.