EFFECT OF CORTISOL AND AGE UPON THE DERMAL CHEMICAL RESPONSE TO DILANTIN

[摘要] Dilantin administration which usually results in profound increases in the dermal concentrations of collagen and insoluble non-collagenous protein, was without effect upon the dermal chemistry of either very old animals or young animals treated with cortisol. Conversely, cortisol administration, which usually results in decreased dermal concentrations of both hexosamine and insoluble collagen was without effect upon young animals receiving Dilantin. Therefore, it would appear that Dilantin and cortisol are antagonistic with respect to their effects upon the chemistry of rat skin.