THE GROWTH OF COCCIDIOIDES IMMITIS IN THE GRANULOMA POUCH OF THE RAT WITH THE DEVELOPMENT OF HYPHAE AND OTHER FORMS

[摘要] The mycelial phase of C. immitis can grow in vivo. The patho-physiology is not completely understood in regard to the conditions under which the mycelial phase of C. immitis develops vivo. Alteration of the local tissue defense mechanism by the use of croton oil and 9-a-fluorohydrocortisone had little effect on this phenomenon. Unusual and bizarre forms as well as forms simulating true budding and conjugation were commonly observed. Such forms were seen when either hyphae or spherules were used as the source of inoculum. However we do not feel that our data is sufficient to prove the occurrence of budding. The concept that C. immitis occurs only in the spherule phase in vivo must be modified to include the mycelial phase.