IDIOPATHIC HYPERLIPEMIA AND PRIMARY HYPERCHOLESTEREMIC XANTHOMATOSIS .3. EFFECTS OF INTRAVENOUSLY ADMINISTERED HEPARIN ON THE PLASMA PROTEINS AND LIPIDS

[摘要] An intravenous injection of 50-100 mg of heparin caused a change in the appearance of the electrophoretic pattern in 2 of 7 normal individuals, in 6 of 8 patients with primary hypercholesteremic xanthomatosis and in 6 of 7 patients with idiopathic hyperlipemia. In all the change consisted of an increase in speed of electrophoretic migration of some of the beta-1 lipoprotein the beta-1 lipoprotein migrated with the speed of either alpha-2, alpha-1 or albumin in the normal individuals and in the patients with primary hypercholesteremic xanthomatosis; while in patients with idiopathic hyperlipemia the excess beta-1 lipoprotein, which even in the native plasma migrated largely with the speed of alpha-2, migrated, after the injection of heparin, faster even than albumin. The pre-albumin component in the electrophoretic pattern of the post-heparin plasma of idiopathic hyperlipemia decreased in size following high speed centrifugation and disappeared following extraction of plasma with ether. Chemical analysis of the pre-albumin component revealed the presence of significant amounts of cholesterol and phospholipids. The degree of turbidity of plasma decreased following injection of heparin in all patients with idiopathic hyperlipemia, although decrease was slight in all but 1 patient. In patients with primary hypercholesteremic xanthomatosis the amount of cholesterol decreased, while in patients with idiopathic hyperlipemia not only the cholesterol decreased, but also the phospholipids and usually the neutral fat decreased.