EFFECTS OF LOCAL THERAPEUTIC AGENTS UPON EPIDERMAL MACROMOLECULAR METABOLISM

[摘要] Effects upon epidermal protein and nucleic acid synthesis of several classes of locally applied therapeutic agents were studied in an invitro system. Amino acid incorporation into protein was stimulated following stratum corneum stripping, exposure to grenz and contact X-rays and after daily applications of sulfur and ammoniated mercury ointment. Salicylic acid caused higher specific activities of epidermal proteins following local application. Prolonged application of surfur ointment or coal tar solution results in inhibition of amino acid incorporation. It is postulated that these substances have several effects upon epidermal, protein synthesis; an early stimulatory effect which is not mediated through RNA fribonucleic acid] and a later inhibitory effect which is associated with inhibition of RNA synthesis.