CLONAL CHARACTERISTICS OF CUTANEOUS T-CELL LYMPHOMAS - CYTOGENETIC EVIDENCE FROM BLOOD, LYMPH-NODES, AND SKIN

[摘要] Chromosome studies were done on mitogen-stimulated lymphocytes from 1 or more tissues (blood, lymph nodes, skin lesions) in 15 patients with mycosis fungoides or Sezary syndrome. A cytogenetically abnormal clone was found in 10 individuals, including 6 with data from several tissues. In 4 cases the same aberrant clone was identified in a skin lesion and in blood and/or lymph node. The abnormal chromosome patterns ranged from hypodiploid to hypertetraploid; there was no evidence of unrelated karyotypically-altered lines at different sites. A 6q- chromosome, previously reported in acute lymphocytic leukemia, was found in 2 patients. Cutaneous T cell lymphomas (CTCL) probably are clonal disorders, presumably unifocal in origin, with the skin lesions populated by cells from the same neoplastic clone that involves lymph nodes and blood.