INFLUENCE OF DOCA ON INDUCED EPIDERMAL CANCERS IN MICE

[摘要] Microscopic observations of squamous cell cancers of skin showed marked difference between animals treated with DOCA [dihydroxycorticosterone acetate] before and after the application of MCA [methylchdanthrene]. The tumors occurring in animals of the DOCA post -treatment group showed characteristic limited growth surrounded by thick connective tissue, spongy edema and moderate amount of hyper- and parakeratosis. The tumors in animals whose skin was DOCA sensitized prior to MCA paintings showed marked upward growth of the neoplastic cells and massive hyper- and parakeratosis. The differential growth pattern of the tumors in the DOCA-treated groups are correlated with the dermal changes produced per se by subcutaneous administration of DOCA alone. The biological behavior of tumors induced in these experiments is compared to the invasive cancers found in cortisone treated mouse skin.