IMMUNOHISTOCHEMICAL STUDIES OF HUMAN CUTANEOUS BASEMENT MEMBRANE-ANCHORING FIBRIL COMPLEX

[摘要] Antiserum to the human cutaneous basement membrane-anchoring fibril complex specifically binds to the basement membrane zone of normal human skin as demonstrated by indirect immunofluorescence and cross reacts with normal human glomerulus. This antiserum does not prevent binding of pemphigoid antibody to its specific antigen; thus the antigen of bullous pemphigoid is unlikely to be a component of the cutaneous basement membrane (basal lamina). The dermal-epidermal junction is an antigenically heterogenous region wherein a number of autoimmune diseases find expression.