COLCHICINE SYNERGISM OF MOUSE HAIR ROOT CHANGES PRODUCED BY X-RAY IRRADIATION

[摘要] The technique for microscopic examination of plucked hairs has been used in mice to demonstrate that colchicine exerts a synergistic effect on dysplastic changes induced in growing hairs by x-ray irradiation. Significant synergism was found only when a specific time interval of 16 hours separates colchicine administration from x-ray irradiation. No protective effect of colchicine was observed in these studies. A clinical response to combined intravenous colchicine and x-ray therapy has been described for a single patient with mycosis fungoides. Such therapy is currently undergoing further evaluation in a group of patients with diverse and advanced malignancies.