Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?

[摘要] Although BRAF V600 mutations in melanocytic tumors are not UVsignature mutations, it is plausible that they could still arise from errorprone replication of UV- damaged DNA. We propose a mechanism for their origin, taking into consideration melanocytic-specific BRAF tandem mutations, nearby potential pyrimidine dimer sites, the properties of specialized DNA polymerases, and biological selection.

[发布日期] 2006-08-01