TAURINE INTOLERANCE IN PSORIASIS

[摘要] Objective evidence of taurine toxicity was found in a group of psoriatic patients. Extension of cutaneous lesions and inc reased scale loss occurred with high taurine intake. Under identical conditions of dietary taurine supplementation, activation of joint lesions took place, with diminished joint mobility and elevation of the blood sedimentation rate. Taurine balance studies were performed in three psoriatic patients and in three control subjects. Negative balance was found in the control group, both during periods of high and low taurine intake. In the patient group, negative balance was found with restricted taurine intake, but positive balance was demonstrated in 2 patients with elevation in the taurine intake. During taurine supplementation, the third patient showed equivalent values for intake and output. Scale losses of taurine increased with the level of taurine consumption. Tests of taurine excretion, after a two gm loading dose of taurine, were carried out in three patients and in one normal subject under controlled dietary conditions. The percentage urinary loss of the administered taurine was less in the psoriatic subjects than in the control when a low basic taurine intake was maintained. These findings were discussed both in relation to the known cases of altered taurine excretion and more specifically in relation to the etiology of psoriasis.