STUDIES ON MECHANISM OF MOLLUSCUM CONTAGIOSUM CYTOTOXICITY

[摘要] The cytopathic activity of molluscum suspensions for amnion cell cultures was augmented and filterable after sonic treatment. A 1 to 3 hr. period of direct contact of inoculum with cells was required to initiate maximal cytopathic changes. Studies employing radioautography and chemicals known to inhibit formation of other viruses suggested that MCA [molluscum cytopathic activity] was not a consequence of infectious virus replica tion. From these results, and from the evidence that cytopathic activity was not adsorbed, it is postulated that the molluscum cytopathic effect may be mediated by a phenomenon acting at the cell surface.