IMMUNOHISTOCHEMICAL STUDIES OF AMYLOID-P COMPONENT DISTRIBUTION IN NORMAL HUMAN-SKIN

[摘要] The distribution of amyloid P component (AP) in normal human skin was investigated by EM and light microscopic immunoperoxidase technique, using antibodies to serum amyloid P component (SAP). AP, or an immunologically cross-reactive protein, was specifically localized to the microfibrils of papillary oxytalan fibers and to the peripheral microfibrillar mantle surrounding the elastin core of mature elastic fibers in the reticular dermis; collagen fibers were not stained with anti-SAP. AP was not detected in the dermal-epidermal basement membrane or in the basement membranes surrounding dermal papillary blood vessels and eccrine structures. These findings establish the detailed distribution of normal tissue AP in the skin and may provide a basis for further studies of the function and behavior of this protein in health and disease.