EFFECTS OF IMMUNOMODULATORY CYTOKINES ON THE PRESENTATION OF TUMOR-ASSOCIATED ANTIGENS BY EPIDERMAL LANGERHANS CELLS

[摘要] The recognition and presentation of tumor-associated antigens by cutaneous antigen-presenting cells (APC) may play an important role in the establishment of effective defense mechanisms against newly emerging tumors in the skin. Recent data demonstrate the ability of I-A+ epidermal cells (Langerhans cells) to present tumor-associated antigens for the induction of protective tumor immunity and elicitation of delayed-type hypersensitivity against the murine spindle cell tumor, S1509a. Furthermore, the local cytokine microenvironment in the vicinity of a cutaneous neoplasm may regulate the ability of resident epidermal APC to initiate and/or to elicit protective immunity against incipient cutaneous neoplasms. This article summarizes the effects of granulocyte-macrophage/colony-stimulating factor (GM-CSF), interleukin-1alpha(IL-1alpha), tumor necrosis factor-alpha(TNFalpha), transforming growth factor-beta (TGFbeta), and interferon-gamma (IFNgamma) on the modulation of antigen presentation by epidermal APC. Our data indicate that these cytokines significantly and differentially modify the ability of epidermal cells to present tumor-associated antigens and that their effects differ with regard to induction of primary immunity (sensitization) or elicitation of secondary immune responses.

[发布日期] 1992-11-01

[效力级别]  Proceedings Paper