RELATIONSHIP OF SUBDERMALLY INJECTED C14-TRIAMCINOLONE ACETONIDE TO OVERLYING SKIN - A RADIOAUTOGRAPHIC STUDY IN MICE

[摘要] To investigate the relationship of the sub-dermally injected, relatively insoluble corticosteroids to the overlying skin, a suspension of C14-labeled triamcinolone acetonide was injected subdermally in mice and studied by radioautography. Sequential changes were observed from 15 min. to 5 days by light microscope. These experiments revealed that a part of the injected hormone moved continuously and uniformly in a centrifugal direction, infiltrating the overlying corium and epidermis. This movement continued at a lesser degree on the 5th day, at which time observation was terminated. The examined skin biopsies from the uninjected sites did not show radioactivity.