EFFECTS OF INDOMETHACIN ON LONG-WAVE ULTRAVIOLET-INDUCED DELAYED ERYTHEMA

[摘要] Indomethacin, a known inhibitor of prostaglandin synthesis, administered topically as a 2.5% solution, intradermally in 10 .mu.g doses, and orally in a dose of 150 mg/day for 2 days to patients did not diminish the delayed erythema produced by long-wave UV light [UVA] (320-400 nm). The delayed phototoxic erythema produced by 8-methoxypsoralen and subsequent exposure to UVA light was similarly unaffected. By comparison, topical and intradermal indomethacin treatment produced sustained decrease in the erythemal response to UV radiation in the UVB [medium range UV light] range (290-320 nm).