ACTION OF SYNTHETIC ANTIMALARIAL DRUGS ON PSORIASIS

[摘要] In a group of 6 patients with generalized psoriasis, synthetic antimalarial drugs induced duplicable effects. The eruption in all became more acute, spread, and in one developed into exfoliative dermatitis. Following withdrawal of the drugs the skin improved distinctly to markedly, and cleared entirely in 2, but relapsed again after a varying interval. The antimalarials could again induce a recrudescence, but this 2nd course took a longer time and larger doses. It was presumed one reason the psoriasis flared under the influence of antimalarial drugs was because they screened out UV light. Persons prone to psoriasis may be obligates of much larger quantities of light than others for their well-being.