GENERAL SWEATING ON HAIRY SKIN OF DOG AND ITS MECHANISMS

[摘要] Infusions of [epinephrine] and [norepinephrine] were made in non-anesthetized dogs at the rate of 1, 3, 6 and 10 jig/kg min. At 6 and 10 jig/kg min. general sweating was caused on the hairy skin in all dogs tested, and even at 1 and 3 /ig/kg min, a definite sweating could be obtained occasionally. General sweating can possibly be produced on the hairy skin of the dog by circulating catecholamines when their secretion from the adrenals is increased. Asphyxiation caused general sweating on the hairy skin of the dog. This sweating could not be abolished by bilateral medullectomy of the adrenal glands. The sweating on aphyxiation, however, did not occur on the sympathetically denervated skin, especially after deprivation of the catecholamine secretion from the adrenals. This fact points to the existence of a sympathetic innervation, very probably adrenergic in nature, to the apocrine glands in the dog''s hairy skin. The sweating on asphyxiation is produced primarily through a nervous mechanism, and subsidiarily through a humoral mechanism.