LOCALIZATION IN KIDNEY OF ANTIBODIES TO HUMAN SKIN AND MALIGNANT MELANOMA

[摘要] Serum antibodies produced in rabbits by Injecting them with human skin or human malignant melanoma gave evidence of reaction in vitro with the following areas in both human and rat kidney sections: stroma surrrounding tubules; basement membrane of glomerular capillaries and Bowman''s capsule; and walls of some blood vessels. In vivo glomerular localization in rat kidney occurred when rabbit antihuman skin and antihuman malignant melanoma serums were injected intravenously. These serums differed in their pattern of localization and associated histologic changes in the renal glomeruli.