MELANIN FORMATION IN VITILIGINOUS SKIN UNDER THE INFLUENCE OF EXTERNAL APPLICATIONS OF 8-METHOXYPSORALEN

[摘要] The effect of 8-methoxypsoralen applied locally and followed by solar or UV radiation was studied in 85 subjects with vitiligo. New pigment was observed in 32. The cosmetic result was acceptable in only 6 Natural sunlight employed in combination with the drug was superior to irradiation from various UV generators. 8-Methoxypsoralen was as effective in this study when used alone as when combined with 8-isoamyleneoxypsoralen. The wave-lengths which are effective in combination with this substance as well as speculations concerning the possible mechanism of action are discussed.