ULTRAVIOLET-LIGHT INDUCES EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY

[摘要] Hairless mice were irradiated with fluorescent sun lamp tubes (peak emission at 313 nm). A significant increase in epidermal ornithine decarboxylase activity was found after 2 h. A maximum 80-fold increase was found after 24 h, decreasing again at 48 h. Epidermal DNA synthesis was decreased at 6 h and 24 h increasing to a maximum 48 h after irradiation. Apparently polyamine biosynthetic enzyme activity precedes the delayed increase in epidermal DNA synthesis following UV light exposure.