PERMEABILITY OF SKIN TO ALBUMIN DEXTRANS AND POLYVINYL PYRROLIDONE

[摘要] The penetration of polymers through excised rabbit and human skin, and rabbit skin in situ, were measured. Radio-iodinated human serum albumin (HSA), polyvinylpyrrolidone (PVP) and dextran were used. All the polymers penetrated excised skin very slowly: PVP penetrated slowest, and a small-M. W. [molecular weight] dextran the fastest. HSA penetrated rabbit skin in situ at a slightly slower rate than excised rabbit skin. The results are interpreted in terms of permeability constants, and compared with similar data for smaller molecules.