HISTOPATHOLOGY OF LICHEN PLANUS BASED ON ANALYSIS OF 100 HUNDRED BIOPSY SPECIMENS

[摘要] The stratem corneum usually does not show parakeratosis. There is usually beading of the granular layer. The epidermis may be atrophic, normal, or moderately hypertrophic. There is usually some liquefaction degeneration at the basal layer. At times this results in the formation of vesicles (Max Joseph spaces) at the dermal-epidermal border. There is usually a characteristic well-defined band-like infiltrate below the basal layer. The infiltrate extends slightly into the epidermis. The infiltrate, although composed principally of small mononuclear cells (lymphocytes), may contain a variable number of epithelioid cells, and occasionally plasma cells and fibroblasts. Eosinophilic degeneration in cells in the epidermis was observed in 37 percent of the biopsy specimens studied. These changes may be of viral origin or may represent early and abnormal keratinization or degeneration.