THIABENDAZOLE INHIBITION OF VENOM NECROSIS

[摘要] Thiabendazole (200 mcg/ml) completely inhibited the tissue damaging activity of cottonmouth moccasin [Agkistrodon piscivorus] venom (300 mcg/ml) when incubated together for 1 hr. at room temperature and injected intradermally into the guinea pig. Thiabendazole (0.15 ml of 200 mcg/ml) injected immediately after the venom decreased tissue damage from cottonmouth moccasin venom (0.05 ml of 600 meg/ ml). Thiabendazole or other chelating agents may be of future value in decreasing tissue damage from venoms containing proteolytic enzymes. The inhibition of proteolytic activity as demonstrated in this paper do not necessarily prove that this is the drug1 s mechanism of anthelmintic or antifungal activity. Thiabendazole has a lethal effect on certain nematodes and fungi.