HISTOLOGIC CHANGES IN IRRADIATED SKIN, AFTER INGESTION OF 8-METHOXYPSORALEN

[摘要] Ultraviolet exposure to skin of subjects ingesting 8-methoxypsoralen results in increased pigmentation and increased thickening of the epidermis, especially the stratum corneum. This stratum corneum thickening seems to result from an increased cohesion of squamous cells so that the outer layers of the stratum corneum scale off less readily. After heavy UV irridation in the 2970 A region, hyaline changes under the stratum corneum appear, similar to stratum licidum on palms and soles. The protective shield effect resulting from this phenomenon against cumulative changes caused by sunlight damage to the skin seems substantiated.