THE CUTANEOUS GLUCOSE TOLERANCE TEST .1. A RATE CONSTANT FORMULA FOR GLUCOSE DISAPPEARANCE FROM THE SKIN

[摘要] Using the intravenous technic, the cutaneous glucose tolerance test has been performed on 30 individuals. Plots of excess skin glucose (on logarithmic scale) versus time (on linear scale) yielded straight lines. At least 6 to 8 post-injection specimens of skin were taken because an occasional specimen was not consistent in its glucose value when compared with the majority of the specimens. The reason for these inconsistencies is probably related to the heterogeneous anatomy of the skin; that is, the irregular distribution of epidermal appendages in the connective tissue of the skin. The glucose disappearance rate constants of blood and skin were determined for each of the test subjects. The data in Table 1 are insufficient to allow conclusions concerning an inter-relationship of the blood and skin glucose tolerance tests; but with this new technic one can determine the rate of disappearance of glucose from human skin. Since a consistent exponential fall of skin excess glucose was observed in all our test subjects, it is highly probable that this first-order kinetic expression (equation II) will be valid for all individuals.