CLINICAL EXPERIENCE WITH THE EFFECT OF ORAL 8-METHOXY-PSORALEN ON THE PIGMENTARY RESPONSES OF THE SKIN TO SUNLIGHT

[摘要] 8-Methoxypsoralen taken by mouth prior to sun exposure augments the skin responses to sunlight. By careful attention to the dose of the drug and to the amount of subsequent sun exposure, it is possible, in many persons, to greatly accentuate the skin''s pigmentary responses to sunlight with little or no increase in the skin''s inflammatory response. We have seen no toxic effects from the oral administration of methoxsalen in doses up to 40 mg daily for many months. Carefully controlled investigative procedures are necessary to determine the safest and most efficient method to use methoxsalen for sun tanning.