LANGERHANS CELLS IN MOUSE SKIN EXPERIMENTALLY DEPRIVED OF ITS NEURAL CREST COMPONENT

[摘要] Langerhans cells were demonstrated in skin developed from neural crest-free grafts originating from the limb bud of 10 day old embryos of the isogenic C57BL/6 mouse strain and transplanted to the spleen of histocompatible adult mice. Melano-cytes were absent from skin differentiated from these neural crest-free grafts, but were present in normal distribution within control neural crest-containing transplants originating from somite regions of the same embryos. On the basis of these experiments Langerhans cells do not belong to the melanocyte lineage of cells, and that they do not stem developmentally from the neural crest. This conclusion is in line with recent evidence derived from other sources referred to.