HISTAMINE IN DELAYED SKIN REACTIONS - FLUOROMETRIC DETERMINATIONS ON PATCH TESTS

[摘要] Analyses of skin histamine in experimental allergic contact dermatitis as well as in induced primary irritant dermatitis in patients with allergic contact dermatitis were carried out by spectrofluorometry. No significant alterations were found in primary irritant reactions or in the initital stages of delayed allergic reactions. After 24 and 48 hours, however, a marked rise in skin histamine was observed in the allergic patch tests. It is suggested that histamine plays a part in allergic contact dermatitis, and that, in patch tests, a significantly higher histamine level is specifically associated with allergic response.