IN VITRO INHIBITION OF CANDIDAL GROWTH BY HUMAN SERUM

[摘要] The ability of sera from normal children to inhibit multiplication of Candida albi-cans in vitro was confirmed. Assay of paired maternal and cord sera showed a normal inhibitory capacity of maternal serum and marked diminution in inhibitory capacity of cord serum. Sera from 5 infants under 3 months did not inhibit candidal growth. Inhibitory capacity was markedly reduced in serum from patients with sickle cell (SC) disease whereas sickle trait (heterozygote) serum inhibited normally. Hemoglobin C trait and SC individuals probably also have a normal capacity to inhibit in vitro reproduction of C. albicans.