INVITRO STUDIES ON THE FUNGISTATIC EFFECT OF ANTIHISTAMINIC DRUGS

[摘要] Benadryl (diphenhydramine HC1), Thenylene (methapyrilene HCl), di+paralene (chlorocylizine HC1), Neo-Antergan (pyriamine maleate), Diatrin (methaphenilene HC1), Thephorin (phenidamine tartrate), Pyribenzamine (tripelennamine HC1), and theophylline ethylenediamine (aminophylline) were tested on cultures on Sabouraud''s maltose agar of Trichophyton schoenleini, T. tonsurans, T. violaceum, T. mentagrophytes, T. concentricum, T. rubrum, Epidermophyton floccosum, Hormodendrum compactum, H. Pedrosoi, Monosporium apiospermum, Phialophora verrucosa, Microsporum canis, M. audouini, M. gypseum, Histoplasma capsulatum. Bastomyces dermatitidis, Candida albicans, Cryptococcus neoformans and Sporotrichum schenckii The descending order of effectiveness of the antihistamine as fungistatic agents was a sfollows: di-paralene, Diatrin, Thephorin, Benadryl, Pyribenzamine, Thenylene, theophylline, and Neo-Antergan. Oi-paralene was the most effective drug tested, having a fungistatic activity in amounts of 0.5 to 0.75 mg./ml. for all the fungi tested, except C. neoformans. which required 2.0 mg./ml. for complete inhibition. The presence of 10% serum in most cases enhanced the fungistatic activity of the drugs. Two exceptions, Neo-Antergan in which the activity was negated and di-paralene in which there was no effect, were observed. No clear evidence of fungicidal activity could be shown for even the most active fungistatic antihistamines, i.e., Thephorin, Diatrin, or Di-paralene.