NEVOXANTHO-ENDOTHELIOMA - A BENIGN XANTHOMATOUS DISEASE OF INFANTS AND CHILDREN

[摘要] Nevoxantho-endothelioma (McDonagh) seems still to be the best diagnostic term to use for a benign xanthomatous disease that usually begins in the first few months of life with the eruption of a few, or occasionally many, soft yellow papules which develop into flat nodules which are often more than 1 cm. in diameter., and are scattered irregularly over the body, extremities and the face. New lesions often appear for a period of months or years and the older ones disappear to leave behind atrophic scar-like areas and there is eventual complete disappearance. There are no apparent systemic involvements and the infants grow normally, and the duration of the disorder is from several months to years. The blood fats are normal and the microscopic picture, while resembling an endothelioma, does at times show typical xanthoma foam cells and Touton giant cells. The disease should be definitely separated from the more serious juvenile xanthoma which is in most cases xanthoma tuberosum multiplex of childhood. Three patients with typical nevoxantho-endothelioma observed over a period of years are reported.