MUCOPOLYSACCHARIDES IN MAST CELLS AND MASTOCYTOSIS

[摘要] A study of 37 cases of mastocytosis revealed no hypocoagulability or other clinical evidence of a significant increase in circulating heparin, with the possible excretion of 1 case. Analysis of 24-hr urine specimens from 21 patients showed normal amounts of total mucopolysaccharide. Paper chromatography and electrophoresis of urine from 10 patients did not demonstrate the presence of heparin. Analysis of random serum samples from 7 patients revealed no increase in blood mucopolysaccharide level. In spite of the great increase in the heparin-containing mast cells in mastocytosis, heparin, unlike histamine, is only rarely released from the mast cells into the circulation in clinically significant amounts.