ORGAN-CULTURE STUDIES OF PEMPHIGUS ANTIBODIES .2. ULTRASTRUCTURAL COMPARISON BETWEEN ACANTHOLYTIC CHANGES INVITRO AND HUMAN PEMPHIGUS LESIONS

[摘要] The ultrastructural and light microscopic features of acantholysis produced in organ culture were compared with those of human pemphigus lesions. In both an intraepidermal split was seen and typical suprabasal acantholytic cells were present. These cells contained small bundles of tonofilaments, usually located away from the cell periphery. Desmosomal plaques with inserted tonofilaments frequently remained along the periphery of acantholytic cells and along the upper portion of the periphery of basal cells. The ultrastructural similarity between in vitro and in vivo lesions shows that organ cultures may provide a valid model for studying the dynamics of pemphigus lesion formation.