EXPERIMENTAL PRODUCTION OF DRUG PHOTOTOXICITY IN GUINEA PIGS

[摘要] Experimental drug phototoxicity to chloropromazine, demethylchlortetracycline and chlor-othiazide was demonstrated in guinea pigs. Following intraperitoneal injection of the drug, the animals were exposed to sunlight for varying periods of time. A positive response was characterized by a brisk erythema and later by necrosis and ulceration of the ears of the experimental animals, a striking contrast to the relatively mild reaction in the control animals. Mylar plastic, which absorbs all wavelengths below 3100 A0, prevents normal erythema from developing in the control animals but has no effect on the phototoxic response. The use of Mylar represents a unique means of enhancing the contrast between control and experimental animals.