C1q: Its functions within the innate and adaptive immune responses and its role in lupus autoimmunity

[摘要] The complement cascade is a multi-faced effector component of the innate immune response. C1q is the recognition component of the classical pathway of complement activation. In addition, C1q has been recognized to serve a number of other biological functions including a modulating role on cellular functions within the adaptive immune response. The importance of Clq to normal immune regulation is reflected by the fact that greater than 90% of individuals who have complete congenital deficiency of Clq have been observed to develop early-onset photosensitive systemic lupus erythematosus (SLE). As a number of single nucleotide polymorphisms have been identified in three Clq genes, it is possible that more subtle variations in C1q expression could be a risk factor for cutaneous LE and SLE. Thus, a more comprehensive delineation of complotype could be of increasing clinical importance in the future.

[发布日期] 2005-07-01

[关键词] C1q;innate immune response;subacute cutaneous lupus erythematosus (SCLE);systemic lupus erythematosus (SLE)