INTRADERMAL TESTS WITH AUTOLOGOUS WHITE BLOOD CELLS IN CHRONIC DISCOID LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS ERYTHEMATOSUS AND CONTROL SUBJECTS

[摘要] Delayed cutaneous hypersensitivity to autologous leukocytes was shown in 17 of 17 patients with acute systemic lupus erythematosus (L. E.) 2 of 2 patients with subacute L. E. and in 10 of 31 patients with chronic discoid L. E. A negative test result was obtained in 2 patients with S. L. E. in remission. Positive tests were elicited also in 3 other distinct groups: patients with leukemia or lymphoma, patients with atopic dermatitis and allergic rhinitis and patients with other dermatoses. Ten healthy control subjects gave negative test results. Evidence to date suggests that the skin reaction to autologous W. B. C. represents a delayed hypersensitivity response against leukocytes mediated through immunologically competent cells rather than serum antibody. The possible significance of positive skin tests to autologous W. B. C. in L. E. and other diseases is discussed.