REGULATION OF THE FREE AMINO ACIDS OF SKIN BY HYDROCORTISONE

[摘要] The action of hydrocor-tisone in decreasing the amino acid concentration of the skin appears to be a result primarily of a direct action of the hormone on the cells of the skin, since the application of hydrocortisone ointment to the skin decreases the free amino acids of the skin without producing any measurable change in the plasma amino acids. Significant decreases in hydraxy-proline, glutamic acid, glycine, valine, cystine, cystathionine, methionine, histidine, carnosine, arginine and lysine in the skin resulted from the administration of hydrocortisone systemically or topically.